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Neural Recordings: Robot Reveals Brain Cells’ Inner Workings
Gaining access to the inner workings of a neuron in the living brain offers a wealth of useful information: its patterns of electrical activity, its shape, even a profile of which genes are turned on at a given moment ...continue
Jurassic Pain: Giant Flea-like Insects Plagued Dinosaurs 165 Million Years Ago
It takes a gutsy insect to sneak up on a huge dinosaur while it sleeps, crawl onto its soft underbelly and give it a bite that might have felt like a needle going in — but giant "flea-like" animals, possibly the oldest of their type ever discovered, probably did just that ...continue
Rare Glimpse of World’s Rarest Gorilla Captured in Video Footage
Conservationists working in Cameroon’s Kagwene Gorilla Sanctuary have collected the first camera trap video footage of the Cross River gorilla. With fewer than 250 individuals remaining, Cross River gorillas are the world’s rarest gorilla and a notoriously elusive species ...continue
Dinosaur Flatulence helped warm Earth
Potty humor just got prehistoric. A new study suggests that dinosaurs may have helped keep an already overheated world warmer with their flatulence and burps 200 million years ago ...continue
Turning Back the Clock to Understand Sex Differences
A research team has found a way to recreate incremental evolutionary steps, turning back the evolutionary clock and watching the transformation of simple antennae into more elaborate ones ...continue
Cell Division more Complex than Previously Thought
The mitotic spindle, an apparatus that segregates chromosomes during cell division, may be more complex than the standard textbook picture suggests, according to researchers at the Harvard School of Engineering and Applied Sciences ...continue
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ARTICLES
Informatics Engine Drives Pharma Development toward Quality by Design
Learning from other industries
Peter J. Boogaard and Hans Griep
The pharmaceutical industry is looking more at holistic approaches to improve the process of bringing new products to market. Adopting these approaches can accelerate product development while lowering operational costs. Quality by Design (QbD) has come relatively late to the pharmaceutical industry
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A Quick Guide to ELN Regulatory Requirements
Charting the best course for rapid approval and favorable review starts with conformity to several agency guidelines
Sandy Weinberg, Ph.D. and Ronald Fuqua, Ph.D.
Ah, for the good old days! Laboratory results were dutifully recorded in bound, hardcover notebooks. Each page was dated and signed, and numbered consecutively. An error was corrected by crossing out (without obliterating) the original entry, then signed and dated to indicate exactly who made the change, when, and (if appropriate) why. Completed notebooks were stored in dry, fireproof file rooms
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Examining the World of ELN
Lessons learned from the 10th annual electronic laboratory notebook conference in Barcelona
Michael H. Elliott
The largest event examining the world of ELN is the annual IQPC ELNs and Advanced Laboratory Solutions conference held September 26-28 in Barcelona, Spain. This three-day event illustrated the evolution of the ELN market, as a majority of attendees have a system in production. This is a significant shift, considering that in 2002 conferees struggled to even define what an ELN should do; the talks were more about concepts than reality
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Hydrogen Bombs & Airline Rants: Changing Mores and Revenue Grabs
web exclusive
Randy C. Hice
The Hydrogen Bomb was set, fused, and ready to go. We were tense. Nervous. Of course, this wasn’t a thermonuclear bomb, it was a garbage bag of hydrogen, tied with a rubber band, with a piece of fuse taped to the side
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Windblown: I-70 Nightmare is a Mirror of Project Futility
web exclusive
Randy C. Hice
I sat atop Dercum Mountain at 11,640 feet above sea level, and faced the brutal winds as I strapped on my snowboard. My youngest son complained about the bitter blast, and I fished a spare balaclava from my pocket. Normally, he’d have worn his bandana as homage to Shaun White, but some poor soul was using it to stop his rather profuse bleeding
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Day of the Iguana: Puerto Rican Road Thrills and Kills
Day of the Iguana
Randy C. Hice
Web Exclusive
At first, my business trip to Puerto Rico had all of the hallmarks of a roaring disaster. To start, the only airline that could deliver me to the Isla Del Encanto in a reasonable time frame was the redoubtable AirTran Airways, whose precursor company, ValueJet, in 1996, managed to auger a plane into the Everglades with 110 people aboard. So poisoned was the brand name that ValueJet was forced to merge with the smaller AirTran just so passengers would cross the jet way to unknowingly throw the dice one more time.
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MULTIMEDIA AND EVENTS
Implementing a Successful Knowledge Management Solution
How to pull it all together to achieve a simple user experience
Suzanne Tracy, Editor in Chief
From drug discovery through approval and monitoring life cycles, a successful knowledge management solution can go a long way toward helping to achieve business goals. But how do you pull it all together to implement a successful platform? Recently, a panel of experts provided guidance on overcoming many of the common challenges — both technological and cultural — that are often associated with implementing a knowledge management solution. Discussion highlights
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PRODUCTS
Accelrys Enterprise Platform
Accelrys Enterprise Platform offers a scientifically aware, service-oriented architecture that enables the integration and deployment of broad scientific solutions spanning data management and informatics, enterprise lab management, modeling and simulation, and workflow automation ...continue
StarDrop 5.2
StarDrop 5.2 features a plug-in module that provides access to Cresset's FieldAlign technology, which offers a unique, three-dimensional insight into the biological activity of compounds ...continue
Sentient Knowledge Explorer 4.0
Sentient Knowledge Explorer 4.0 is semantic data integration and knowledge management software for life sciences and healthcare ...continue
ChemBook Electronic Laboratory Notebook
The ChemBook electronic laboratory notebook (ELN) features an optional Reactor Engine Parallel Synthesis add-on to support the workflows of chemists, synthesizing libraries of compounds in a parallel fashion ...continue
Reaction Genius Software Platform
Reaction Genius software platform is designed to enable better chemistry knowledge sharing and workflow productivity. The application enables rapid chemical reaction search and chemistry analytics for electronic laboratory notebook (ELN) platforms ...continue
LabSolutions DB Software
LabSolutions DB offers LC/GC laboratories fast and secure management for their LC/GC data. The software integrates a data management function with LabSolutions LC/GC control and analysis software ...continue
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