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State of the ELN Market: A look back at the past 12 months

August 8, 2012 11:36 am | by Michael H. Elliott | Comments

Over the last 12 months, the market for ELN technology has evolved from one dominated by sales to a handful of large biotechnology and pharmaceutical companies, to a diverse landscape of markets and organizations. This has caused a sea-change in both how suppliers approach the market and the features they offer

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World of Pure Imagination: On the rise of materials informatics

August 8, 2012 11:31 am | by William Weaver, Ph.D. | Comments

We have enjoyed a century of innovation and productivity since Henry Ford and the Ford Motor Company developed the assembly line manufacturing process over the years of 1908 to 1915. While originally proposed by Adam Smith in his work The Wealth of Nations, published in 1776, Ford popularized the method of progressive assembly

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Informatics: The Glue to Build Enterprise Knowledge

August 8, 2012 11:13 am | by Peter Boogaard | Comments

Extreme cost pressure, consumers demanding reliability and loss of market share were key drivers for the electronic and car industry to adopt Juran’s1successful QbD theory. It is proven that his theory to adopt continuous improvement strategies to decrease variability resulted in significantly better products and financial performance

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The GPU Performance Revolution

August 8, 2012 8:30 am | Comments

Five years ago, NVIDIA disrupted “business as usual” in the high performance computing industry with the release of CUDA in February 2007. The September 2011 announcement by the Texas Advanced Computer Center (TACC) of a MIC-based (Many Integrated Core) Stampede supercomputer shows that Intel has decided to compete against graphics processing units (GPU) and other computer architectures in the “leadership class” HPC market space with the Knights Corner (KNC) many-core processor chip

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Introducing a Paperless Lab

August 8, 2012 8:09 am | by Ulf Fuchslueger and Andreas Schild | Comments

Laboratories working in the pharmaceutical industry in the areas of R&D and quality control find themselves increasingly having to cope with conflicting demands — tougher regulatory requirements and harsher economic realities. In order to meet these demands, new ways of dealing with process, data and system management are necessary.

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Seven Key Validation Factors for IT Systems in the Lab

August 8, 2012 7:56 am | Comments

Everyone working in a regulatory lab these days knows that everything must be validated. And that “everything” includes analytical methods, instruments and also the IT systems

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Positioning x86 Petascale Performance with MIC Architecture

August 8, 2012 7:39 am | Comments

The Texas Advanced Computing Center (TACC) announcement of their forthcoming 10 petaflop/s Stampede supercomputer utilizing the Intel Many Integrated Core (MIC) architecture demonstrates a substantial commitment by Intel to design hardware to accelerate highly-parallel workloads

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ELN in the Bioanalytical Laboratory

August 8, 2012 7:26 am | by Michael H. Elliott | Comments

Bioanalytical laboratories play a crucial role in the development of pharmaceutical drug products. Labs in large biopharmaceutical companies typically partner with other internal groups, such as pre-clinical toxicology and clinical pharmacology, to support their analytical requirements.

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A Run on the Bank: Crowdsourcing open source software for biobanking

August 8, 2012 7:15 am | Comments

In the fall of 2008, software developers Jeff Atwood and Joel Spolsky launched an online forum encouraging programmers to post questions that were answered by fellow visitors to the site. Called Stack Overflow, it was not the first programmer’s forum to elicit expert advice from visitors, however, it was one of the first to be totally free to its users

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The Manga Guide to Relativity: Real Relativity, Real Easy!

May 10, 2012 12:43 pm | by John A. Wass, Ph.D. | Comments

Making an intensely complex subject understandable to the non-physicist John A. Wass, Ph.D. Well, relatively! I didn’t ask to review this book, but my wonderful contact at No Starch Press (read Geeks Anonymous) sent The Manga Guide to Relativity thinking that the subject may interest me. After sitting on it for too many months, I finally got around to reading a few pages. After 10 pages, I was hooked

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Informatics Engine Drives Pharma Development toward Quality by Design

May 10, 2012 12:20 pm | by Peter J. Boogaard and Hans Griep | Comments

Learning from other industries Peter J. Boogaard and Hans Griep The pharmaceutical industry is looking more at holistic approaches to improve the process of bringing new products to market. Adopting these approaches can accelerate product development while lowering operational costs. Quality by Design (QbD) has come relatively late to the pharmaceutical industry

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SC11 Conference Spotlights Globalization of HPC Leadership

May 10, 2012 12:13 pm | by Steve Conway | Comments

Exascale strategies are all over the map Steve Conway The recent SC11 supercomputing conference in Seattle attracted nearly 12,000 attendees, a record high that reflects the growing vibrancy of the worldwide HPC community. The show revealed some interesting innovations, especially in memory and networking technologies, but the real spotlight was on the globalization of HPC leadership

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A Quick Guide to ELN Regulatory Requirements

May 10, 2012 12:09 pm | by Sandy Weinberg, Ph.D. and Ronald Fuqua, Ph.D. | Comments

Charting the best course for rapid approval and favorable review starts with conformity to several agency guidelines Sandy Weinberg, Ph.D. and Ronald Fuqua, Ph.D. Ah, for the good old days! Laboratory results were dutifully recorded in bound, hardcover notebooks. Each page was dated and signed, and numbered consecutively. An error was corrected by crossing out (without obliterating) the original entry, then signed and dated to indicate exactly who made the change, when, and (if appropriate) why. Completed notebooks were stored in dry, fireproof file rooms

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Examining the World of ELN

May 10, 2012 12:00 pm | by Michael H. Elliott | Comments

Lessons learned from the 10th annual electronic laboratory notebook conference in Barcelona Michael H. Elliott The largest event examining the world of ELN is the annual IQPC ELNs and Advanced Laboratory Solutions conference held September 26-28 in Barcelona, Spain. This three-day event illustrated the evolution of the ELN market, as a majority of attendees have a system in production. This is a significant shift, considering that in 2002 conferees struggled to even define what an ELN should do; the talks were more about concepts than reality

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Good Experimental Design Pays Dividends Continuously

May 10, 2012 11:24 am | by Mark A. Anawis | Comments

Judicious selection of a logical sequence of designs leads to a model that pays for itself Mark A. Anawis The journalist David Brinkley once said “A successful man is one who can lay a firm foundation with the bricks others have thrown at him.” In science and engineering, a good experimental design is the key to a successful product, as well as understanding a process. A good design creates a useful mathematical model that can be used to understand and optimize a process.

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