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Make No Little Plans

August 8, 2012 12:15 pm | Comments

Ongoing advances in scientific technology have left us confronted with the task of discovering scientific knowledge from enormous amounts of data generated in the life and environmental sciences, physics and sociology, business and medicine. In biology, these data are frequently combined from many sources. Further, addressing large-scale interdisciplinary problems requires diverse research teams. Researchers in biology, particularly in computational biology and systems biology, already have experienced the shift from the one-scientist-one-project paradigm to cross-disciplinary collaborative research, and the need for an infrastructure and community that can support it all


Developing a Technology Roadmap for Data-intensive Computing

August 8, 2012 12:00 pm | Comments

Technology and computational evangelists quickly learn that human psychology is a key component of any project roadmap. The truth in the quip that it took one social genius plus 500,000 scientists and engineers to put a man on the moon can be appreciated when one observes the social issues that surface in technical discussions within even small groups of people. As the name implies, data-intensive computing requires large amounts of data


State of the ELN Market: A look back at the past 12 months

August 8, 2012 11:36 am | by Michael H. Elliott | Comments

Over the last 12 months, the market for ELN technology has evolved from one dominated by sales to a handful of large biotechnology and pharmaceutical companies, to a diverse landscape of markets and organizations. This has caused a sea-change in both how suppliers approach the market and the features they offer


World of Pure Imagination: On the rise of materials informatics

August 8, 2012 11:31 am | by William Weaver, Ph.D. | Comments

We have enjoyed a century of innovation and productivity since Henry Ford and the Ford Motor Company developed the assembly line manufacturing process over the years of 1908 to 1915. While originally proposed by Adam Smith in his work The Wealth of Nations, published in 1776, Ford popularized the method of progressive assembly


Informatics: The Glue to Build Enterprise Knowledge

August 8, 2012 11:13 am | by Peter Boogaard | Comments

Extreme cost pressure, consumers demanding reliability and loss of market share were key drivers for the electronic and car industry to adopt Juran’s1successful QbD theory. It is proven that his theory to adopt continuous improvement strategies to decrease variability resulted in significantly better products and financial performance


The GPU Performance Revolution

August 8, 2012 8:30 am | Comments

Five years ago, NVIDIA disrupted “business as usual” in the high performance computing industry with the release of CUDA in February 2007. The September 2011 announcement by the Texas Advanced Computer Center (TACC) of a MIC-based (Many Integrated Core) Stampede supercomputer shows that Intel has decided to compete against graphics processing units (GPU) and other computer architectures in the “leadership class” HPC market space with the Knights Corner (KNC) many-core processor chip


Introducing a Paperless Lab

August 8, 2012 8:09 am | by Ulf Fuchslueger and Andreas Schild | Comments

Laboratories working in the pharmaceutical industry in the areas of R&D and quality control find themselves increasingly having to cope with conflicting demands — tougher regulatory requirements and harsher economic realities. In order to meet these demands, new ways of dealing with process, data and system management are necessary.

Siri Segalstad is Principal, Segalstad Consulting AS and the author of International IT Regulations and Compliance (Wiley-Blackwell, 2008).

Seven Key Validation Factors for IT Systems in the Lab

August 8, 2012 7:56 am | by Siri H. Segalstad | Comments

Everyone working in a regulatory lab these days knows that everything must be validated. And that “everything” includes analytical methods, instruments and also the IT systems


Positioning x86 Petascale Performance with MIC Architecture

August 8, 2012 7:39 am | Comments

The Texas Advanced Computing Center (TACC) announcement of their forthcoming 10 petaflop/s Stampede supercomputer utilizing the Intel Many Integrated Core (MIC) architecture demonstrates a substantial commitment by Intel to design hardware to accelerate highly-parallel workloads


ELN in the Bioanalytical Laboratory

August 8, 2012 7:26 am | by Michael H. Elliott | Comments

Bioanalytical laboratories play a crucial role in the development of pharmaceutical drug products. Labs in large biopharmaceutical companies typically partner with other internal groups, such as pre-clinical toxicology and clinical pharmacology, to support their analytical requirements.


A Run on the Bank: Crowdsourcing open source software for biobanking

August 8, 2012 7:15 am | Comments

In the fall of 2008, software developers Jeff Atwood and Joel Spolsky launched an online forum encouraging programmers to post questions that were answered by fellow visitors to the site. Called Stack Overflow, it was not the first programmer’s forum to elicit expert advice from visitors, however, it was one of the first to be totally free to its users


The Manga Guide to Relativity: Real Relativity, Real Easy!

May 10, 2012 12:43 pm | by John A. Wass, Ph.D. | Comments

Making an intensely complex subject understandable to the non-physicist John A. Wass, Ph.D. Well, relatively! I didn’t ask to review this book, but my wonderful contact at No Starch Press (read Geeks Anonymous) sent The Manga Guide to Relativity thinking that the subject may interest me. After sitting on it for too many months, I finally got around to reading a few pages. After 10 pages, I was hooked


Informatics Engine Drives Pharma Development toward Quality by Design

May 10, 2012 12:20 pm | by Peter J. Boogaard and Hans Griep | Comments

Learning from other industries Peter J. Boogaard and Hans Griep The pharmaceutical industry is looking more at holistic approaches to improve the process of bringing new products to market. Adopting these approaches can accelerate product development while lowering operational costs. Quality by Design (QbD) has come relatively late to the pharmaceutical industry

Steve Conway, Research VP, IDC High Performance Computing Group

SC11 Conference Spotlights Globalization of HPC Leadership

May 10, 2012 12:13 pm | by Steve Conway | Comments

Exascale strategies are all over the map Steve Conway The recent SC11 supercomputing conference in Seattle attracted nearly 12,000 attendees, a record high that reflects the growing vibrancy of the worldwide HPC community. The show revealed some interesting innovations, especially in memory and networking technologies, but the real spotlight was on the globalization of HPC leadership


A Quick Guide to ELN Regulatory Requirements

May 10, 2012 12:09 pm | by Sandy Weinberg, Ph.D. and Ronald Fuqua, Ph.D. | Comments

Charting the best course for rapid approval and favorable review starts with conformity to several agency guidelines Sandy Weinberg, Ph.D. and Ronald Fuqua, Ph.D. Ah, for the good old days! Laboratory results were dutifully recorded in bound, hardcover notebooks. Each page was dated and signed, and numbered consecutively. An error was corrected by crossing out (without obliterating) the original entry, then signed and dated to indicate exactly who made the change, when, and (if appropriate) why. Completed notebooks were stored in dry, fireproof file rooms



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