NASA aims to improve the sonic environment Mehdi R. Khorrami, Ph.D. and Patrick J. Moran, Ph.D. A key challenge in aircraft design is to minimize the noise radiated during take-off and landing. Increasingly strict U.S. regulations on noise pollution surrounding airports near major metropolitan areas mandate that aircraft that do not meet noise requirements be retrofitted or removed from service
Visual analysis in this fast-growing, diverse field demands new ways of leveraging HPC resources Aaron Knoll The explosion of nanoscale research driven by computational chemistry is changing how materials are modeled, validated and synthesized. More than ever, research in energy storage, catalysis and alternative fuels is being conducted in a computational sandbox before it is validated experimentally and, ultimately, manufactured
A new international study confirms that whilst snow has an insulating effect which helps plants to grow bigger, heavy and prolonged snow can, in certain circumstances, also encourage the rapid and extensive growth of killer fungal strains. The snowfall can bring about unexpected conditions that encourage fungal growth, leading to the death of plants in the Arctic
Building the foundation web exclusive Bennett Lass Ph.D This is the second article in a series on best practices in implementing an Electronic Laboratory Notebook (ELN). The previous article identified five core areas which will optimize return on investment (ROI) and ensure a successful ELN deployment. This article discusses the first core area: Establishing a Solid Foundation
How do you define and manage success? web exclusive Bennett Lass Ph.D In the past five years, the electronic lab notebook (ELN) has moved from nascent technology deployed mainly by early adopters and technology enthusiasts to a mainstream laboratory chemical informatics platform. Atrium Research and Consulting estimates that over 25% of the potential market for ELNs has either deployed or is in the midst of deploying an ELN
Laboratory informatics can take on many guises. John R. Joyce, Ph.D While most users may only be familiar with it in regards to laboratory information management systems (LIMS) or chromatography data systems (CDS), its reach is considerably broader than that. An example of this, which has the potential for directly improving a great many lives in the future, goes under the somewhat innocuous acronym of i2b2
he title refers to the editor’s angst at using most genomics software for gene expression (microarray) studies. I keep asking myself why they make it so hard. For those chemists, physicists and engineers in our readership not into pharmacogenomics, I specifically refer to the data acquisition phase.
How HPC is transforming biological research Mark Borodovsky and David A. Bader As a new era centered on human health dawns around the world, the life sciences — accelerated by the tremendous bloom of genomics — are poised to open new horizons. And, in this relatively new, interdisciplinary branch of biology called genomics, computing plays a critical role
Balance should be maintained over the life of the system Michael H. Elliott For many years, information security was primarily concerned with avoiding system and network breaches by outside hackers. But now, the number of criminal cases where internal employees are stealing intellectual property is increasing
This rising supercomputing power is reaching for real-world HPC leadership Steve Conway The United States has lost the nominal supercomputing title twice — both times in the past decade to an Asian country. I say “nominal,” because the most widely recognized title is the top spot on the semi-annual list of the world’s Top500 supercomputers
10 essential chromatography data system compliance areas R.D. McDowall This article explores the steps necessary to ensure the integrity of data generated and maintained by chromatography data systems (CDS) in a regulated GXP environment. It has been driven partly by recent content of some U.S. Food and Drug Administration (FDA) warning letters and the publication of the new European Union (EU) GMP Annex 11 regulations
Cloud computing can offer a convenient, “faster, cheaper, greener” option than hardware ownership Rob Farber “Faster, better, cheaper” and “green computing” are common themes in general and high-performance computing nowadays. Cloud computing is an alternative application model that allows users to run small to very, very large distributed applications leveraging the idle computational resources at a number of institutions and data centers
This month’s column reviews a book from three of my former colleagues at Abbott Laboratories. Their areas of expertise are toxicogenomics, pharmacogenomics and oncology. Naturally, the subject matter reflects the authors’ research interests.
John R. Joyce, Ph.D. The Crimson Project is about the development of an application, called Crimson, designed to address the always critical shortage of samples in clinical research
The rise of master data integration William Weaver, Ph.D. Back when speed and capacity required large amounts of matter and space, centralized IT was king, and users submitted computational requests via slow terminals. The ensuing evolution toward ever faster speed and higher capacity of shrinking devices led to decentralized IT in the form of personal hard-drives and portable memory — and, along with it, an imperative to manage all of the disparate data