Scientists have used computer simulations to show how bacteria are able to destroy antibiotics — a breakthrough that will help develop drugs which can effectively tackle infections in the future. Researchers at the University of Bristol focused on the role of enzymes in the bacteria, which split the structure of the antibiotic and stop it from working, making the bacteria resistant.
UC Irvine will receive $8 million from the NIH to establish one of six national centers...
Mathematics might be able to reduce the need for invasive biopsies in patients suffering kidney...
Sentira is a desktop application designed to provide elegant and dynamic visualization for compound data. The software is applicable across many fields of chemistry, enabling users to quickly find patterns in compound data, visualize structure-activity relationships and present and report results.
The 22nd International Molecular Medicine Tri-Conference is the industry's Preeminent Event on Molecular Medicine, focusing on Drug Discovery, Genomics, Diagnostics and Information Technology. Spanning six days this year, the Tri-Conference includes an expanded program that includes 6 symposia, over 20 short courses, and 17 conference programs.
SLAS is a global organization that provides forums for education and information exchange to encourage study and professional collaboration aimed at advancing laboratory science and technology for the drug discovery, biotechnology, chemical, data informatics, clinical diagnostic, consumer product, pharmaceutical, and other industries.
The Program Committee has announced a call for papers for the Pittcon 2015 Technical Program. Abstracts are currently being accepted for contributed oral and poster presentations in areas such as, but not limited to, analytical chemistry, applied spectroscopy, life science, bioanalysis, food science, nanotechnology, environmental science and pharmaceutical. The 2015 committee is especially interested in topics relevant to energy and fuels.
Is Big Data really the biggest challenge at the moment for translational science? Certainly there are issues with the complexity and size of omics data, which Big Data techniques can help address, but there are two more pressing challenges: enabling collaboration whilst facilitating information sharing, and the ability to better interpret multiple different omics data (multi-omics).
A large number of neglected diseases exist in which each disease has only a small number of patients in the world, yet the number is still significant. Kun-Yi Hsin is working on precisely this problem. In a recent article, he describes his work identifying potential drugs and targets for those drugs using a computational approach that has the potential to bring the cost of drug development down while increasing the speed of drug discovery.
ScienceCloud is an SaaS-based information management and collaboration workspace for externalized life science research and development. It is designed to advance collaborative drug discovery with a new generation of integrated applications built on a scalable, cloud-based scientific platform.
Data Integrity in a Nutshell: Industry must take bold steps to assure the data used for drug quality decisions is trustworthyJanuary 7, 2014 12:31 pm | by Mark E. Newton | Articles | Comments
Regulatory inspectors have started digging much deeper into data, no longer accepting batch release data and supportive testing at face value. Even worse, this effort is justified: they have cited a number of firms for violations of data integrity, a most fundamental bond of trust between manufacturers and the regulators that inspect them. Industry must take bold steps to assure the data used for drug quality decisions is trustworthy...
Researchers at Stanford and Google have conducted an unprecedented, atom-scale simulation of the receptor site's transformation, a feat that could have significant impact on drug design.
Scientist at Charité – Universitätsmedizin Berlin have used a computer simulation for predicting the effectiveness of various combination therapies for colon tumors. In most tumors, the communication between the individual cells is disturbed and the cells permanently receive growth and survival signals. For this reason, drugs are increasingly used in modern tumor therapy that targets those molecules to shut down these faulty signals.
Although we know the tool's general purpose, it can sometimes be difficult to tell if a specific pair of precision tweezers belongs to a surgeon or a master jeweller. It is now easier to solve similar conundrums about a type of protein that allows cells to react to their environment, thanks to scientists at the European Molecular Biology Laboratory (EMBL). Published in Science Signaling,...
Certara, a leading provider of software and scientific consulting services to improve productivity and decision-making from drug discovery through clinical development, announced that Certara and ChemAxon have signed a partnership agreement. The partnership will focus on providing seamless access to ChemAxon’s MarvinSketch and JChem Cartridge for Oracle via Certara’s D360.
The bioisostere replacement tool, FieldStere is a fast and powerful software tool that uses innovative field-point technology, together with a database of molecular fragments, to help guide drug discovery projects and generate new intellectual property.
Bacteria are common sources of infection, but these microorganisms can themselves be infected by even smaller agents: viruses. A new analysis of the interactions between bacteria and viruses has revealed patterns that could help scientists working to understand which viruses infect which bacteria in the microbial world
A yet unidentified component of coffee interacts with the beverage’s caffeine, which could be a surprising reason why daily coffee intake protects against Alzheimer’s disease. A new Alzheimer’s mouse study found that this interaction boosts blood levels of a critical growth factor that seems to fight off the Alzheimer’s disease process
A new international study confirms that whilst snow has an insulating effect which helps plants to grow bigger, heavy and prolonged snow can, in certain circumstances, also encourage the rapid and extensive growth of killer fungal strains. The snowfall can bring about unexpected conditions that encourage fungal growth, leading to the death of plants in the Arctic
Scientists have confirmed that chytridiomycosis, a rapidly spreading amphibian disease, has reached a site near Panama’s Darien region. This was the last area in the entire mountainous neotropics to be free of the disease
Deadly bacteria may be evolving antibiotic resistance by mimicking human proteins, according to a new study. This process of “molecular mimicry” may help explain why bacterial human pathogens, many of which were at one time easily treatable with antibiotics, have re-emerged in recent years as highly infectious public health threats
A potential life-saving treatment for severe E. coli food poisoning outbreaks — developed more than a decade ago — hasn't gone forward into clinical trials because of lack of commercial interest. Researchers produced a "designer" probiotic bacterium which binds and neutralizes the toxin produced by E. coli
LifeScope 2.0 Genomic Analysis Software is a bioinformatics system for analyzing data from genomic sequencing instruments to study human disease such as cancer. The product features secure project management, pushbutton workflows and an intuitive user interface
In addition to its damaging effect on the environment researchers have now linked e-waste to adverse effects on human health, such as inflammation and oxidative stress – precursors to cardiovascular disease, DNA damage and possibly cancer. Researchers took air samples from one of the largest e-waste dismantling areas in China and examined their effects on human lung epithelial cells
Seeing ultraviolet light allows reindeer to take in live-saving information in conditions where normal mammalian vision would make them vulnerable to starvation, predators and territorial conflict. It also raises the question of how reindeer protect their eyes from being damaged by UV
A new analysis has found that allowing full access to personal medical records increases satisfaction without increasing anxiety in newly diagnosed cancer patients. The study indicates that providing accurate information to patients through medical records can be a beneficial complement to verbal communication with their physicians
This month’s column reviews a book from three of my former colleagues at Abbott Laboratories. Their areas of expertise are toxicogenomics, pharmacogenomics and oncology. Naturally, the subject matter reflects the authors’ research interests.
John R. Joyce, Ph.D. The Crimson Project is about the development of an application, called Crimson, designed to address the always critical shortage of samples in clinical research
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