A large number of neglected diseases exist in which each disease has only a small number of patients in the world, yet the number is still significant. Kun-Yi Hsin is working on precisely this problem. In a recent article, he describes his work identifying potential drugs and targets for those drugs using a computational approach that has the potential to bring the cost of drug development down while increasing the speed of drug discovery.
ScienceCloud is an SaaS-based information management and collaboration workspace for...
Data Integrity in a Nutshell: Industry must take bold steps to assure the data used for drug quality decisions is trustworthyJanuary 7, 2014 12:31 pm | by Mark E. Newton | Articles | Comments
Regulatory inspectors have started digging much deeper into data, no longer accepting batch...
Researchers at Stanford and Google have conducted an unprecedented, atom-scale simulation of the...
Scientist at Charité – Universitätsmedizin Berlin have used a computer simulation for predicting the effectiveness of various combination therapies for colon tumors. In most tumors, the communication between the individual cells is disturbed and the cells permanently receive growth and survival signals. For this reason, drugs are increasingly used in modern tumor therapy that targets those molecules to shut down these faulty signals.
Although we know the tool's general purpose, it can sometimes be difficult to tell if a specific pair of precision tweezers belongs to a surgeon or a master jeweller. It is now easier to solve similar conundrums about a type of protein that allows cells to react to their environment, thanks to scientists at the European Molecular Biology Laboratory (EMBL). Published in Science Signaling,...
Certara, a leading provider of software and scientific consulting services to improve productivity and decision-making from drug discovery through clinical development, announced that Certara and ChemAxon have signed a partnership agreement. The partnership will focus on providing seamless access to ChemAxon’s MarvinSketch and JChem Cartridge for Oracle via Certara’s D360.
The bioisostere replacement tool, FieldStere is a fast and powerful software tool that uses innovative field-point technology, together with a database of molecular fragments, to help guide drug discovery projects and generate new intellectual property.
Bacteria are common sources of infection, but these microorganisms can themselves be infected by even smaller agents: viruses. A new analysis of the interactions between bacteria and viruses has revealed patterns that could help scientists working to understand which viruses infect which bacteria in the microbial world
A yet unidentified component of coffee interacts with the beverage’s caffeine, which could be a surprising reason why daily coffee intake protects against Alzheimer’s disease. A new Alzheimer’s mouse study found that this interaction boosts blood levels of a critical growth factor that seems to fight off the Alzheimer’s disease process
A new international study confirms that whilst snow has an insulating effect which helps plants to grow bigger, heavy and prolonged snow can, in certain circumstances, also encourage the rapid and extensive growth of killer fungal strains. The snowfall can bring about unexpected conditions that encourage fungal growth, leading to the death of plants in the Arctic
Scientists have confirmed that chytridiomycosis, a rapidly spreading amphibian disease, has reached a site near Panama’s Darien region. This was the last area in the entire mountainous neotropics to be free of the disease
Deadly bacteria may be evolving antibiotic resistance by mimicking human proteins, according to a new study. This process of “molecular mimicry” may help explain why bacterial human pathogens, many of which were at one time easily treatable with antibiotics, have re-emerged in recent years as highly infectious public health threats
A potential life-saving treatment for severe E. coli food poisoning outbreaks — developed more than a decade ago — hasn't gone forward into clinical trials because of lack of commercial interest. Researchers produced a "designer" probiotic bacterium which binds and neutralizes the toxin produced by E. coli
LifeScope 2.0 Genomic Analysis Software is a bioinformatics system for analyzing data from genomic sequencing instruments to study human disease such as cancer. The product features secure project management, pushbutton workflows and an intuitive user interface
In addition to its damaging effect on the environment researchers have now linked e-waste to adverse effects on human health, such as inflammation and oxidative stress – precursors to cardiovascular disease, DNA damage and possibly cancer. Researchers took air samples from one of the largest e-waste dismantling areas in China and examined their effects on human lung epithelial cells
Seeing ultraviolet light allows reindeer to take in live-saving information in conditions where normal mammalian vision would make them vulnerable to starvation, predators and territorial conflict. It also raises the question of how reindeer protect their eyes from being damaged by UV
A new analysis has found that allowing full access to personal medical records increases satisfaction without increasing anxiety in newly diagnosed cancer patients. The study indicates that providing accurate information to patients through medical records can be a beneficial complement to verbal communication with their physicians
This month’s column reviews a book from three of my former colleagues at Abbott Laboratories. Their areas of expertise are toxicogenomics, pharmacogenomics and oncology. Naturally, the subject matter reflects the authors’ research interests.
John R. Joyce, Ph.D. The Crimson Project is about the development of an application, called Crimson, designed to address the always critical shortage of samples in clinical research
Scientists are to investigate how lethal viruses attack differently sized populations of moths in research that may help develop new methods of pest control. The project will study the grain-infesting Indian meal moth ( Plodia interpunctella ) and a virus it carries that is sometimes deadly to its host and sometimes not
Superantigens, the toxins produced by staphylococcus bacteria, are more complex than previously believed, reveals a team of researchers. Their discovery shows that the body's immune system can cause more illnesses than realized
About two percent of the population has a condition called synesthesia, in which two different sensations, like color and sound, are experienced at once. Although this condition is rare, the new findings suggest the brain is wired in complex and sometimes overlapping ways to help people interpret and understand their environments
The new inhalable antibiotic is a dry powder, comprised of fine particles of antibiotics. These particles are targeted to the deep lung where TB enters in early stages of infection
Scientists have observed the highest rate of beak abnormalities ever recorded in wild bird populations in Alaska and the Northwest. The study on beak deformities in northwestern crows in Alaska, Washington and British Columbia follows a trend found earlier in Alaska's black-capped chickadees
The patented microchip has the size of a one euro coin, incorporating a small channel along which a sample of blood containing the patient's tumor cells flows. By means of ultrasonic waves focused on a specific zone, these cells, having a density and size different from the rest, concentrate at the point from where they are gathered
GastroPlus Version 7.0 is software for the simulation of drug absorption, pharmacokinetics, and pharmacodynamics. This version was in development for two years and required major architectural changes to the program
New studies find that induced pluripotent stem cells (iPS) from mouse somatic cells in vitro have "implications for overcoming immunological rejection" and transplanted liver cells from widely divergent species can function to correct acute liver failure and prolong survival
Monarch butterflies appear to use medicinal plants to treat their offspring for disease, research by biologists shows. Female butterflies prefer to lay their eggs on plants that will make their offspring less sick, suggesting that monarchs have evolved the ability to medicate their offspring
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