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Left to right: Ron Weiss, professor of biological engineering; Domitilla Del Vecchio, associate professor of mechanical engineering; and Deepak Mishra, MIT graduate student in biological engineering. Courtesy of Brian Teague

New Device could make Large Biological Circuits Practical

November 26, 2014 1:49 pm | by David L. Chandler, MIT | News | Comments

Researchers have made great progress in recent years in the design and creation of biological circuits — systems that, like electronic circuits, can take a number of different inputs and deliver a particular kind of output. But, while individual components of such biological circuits can have precise and predictable responses, those outcomes become less predictable as more such elements are combined.

Evidence-based Medicine: Bringing Big Data to Healthcare Consumers

November 26, 2014 9:31 am | by Kalorama Information | News | Comments

The IBM Watson Group's investment in Pathway Genomics is a model for the types of partnerships...

High Performance Computing for All (Yes, You Too…)

November 19, 2014 1:34 pm | by Gilad Shainer, HPC Advisory Council | Blogs | Comments

High-performance computing can help a business to become more efficient and more productive. And...

Exploration and Analysis of DNA Microarray and Other High-Dimensional Data

November 18, 2014 3:10 pm | by John A. Wass, Ph.D. | Articles | Comments

The introduction of newer sequencing methodologies, DNA microarrays and high-throughput...

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The Center for Pediatric Genomic Medicine at Children’s Mercy was the first genome center in the world inside children’s hospital and one of the first to focus on genome sequencing and analysis for inherited childhood diseases.

HPC Innovation Excellence Award: The Center for Pediatric Genomic Medicine

November 17, 2014 6:40 pm | Award Winners

The Center for Pediatric Genomic Medicine at Children's Mercy Hospitals Kansas City was the first genome center in the world to be created inside a children's hospital and one of the first to focus on genome sequencing and analysis for inherited childhood diseases. 

IBM and Pathway Genomics are aiming to revolutionize the health and wellness industry by leveraging the natural language processing and cognitive capabilities of Watson. For the first time consumers will be able to ask the Pathway Panorama app questions t

IBM Watson Group Invests in Pathway Genomics

November 13, 2014 2:28 pm | by IBM | News | Comments

Cognitive apps are in market today and continue to change the way professionals and consumers make decisions. To help accelerate this transformation, the IBM Watson Group announced an investment in Pathway Genomics, a clinical laboratory that offers genetic testing services globally, to help deliver the first-ever cognitive consumer-facing app based on genetics from a user’s personal makeup.

Vintana during the age of the dinosaurs. Courtesy of Lucille Betti-Nash

Paleontologists Find Ancient, Bizarre Groundhog-like Mammal

November 5, 2014 4:37 pm | by Stony Brook University | News | Comments

A newly discovered 66 to 70 million-year-old groundhog-like creature, massive in size compared to other mammals of its era, provides new and important insights into early mammalian evolution. Stony Brook University paleontologist David Krause, Ph.D., led the research team that unexpectedly discovered a nearly complete cranium of the mammal, which lived alongside Late Cretaceous dinosaurs in Madagascar.

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GeneSpring Pathway Architect Software

GeneSpring Pathway Architect Software

November 3, 2014 11:44 am | Agilent Technologies | Product Releases | Comments

GeneSpring Pathway Architect software is designed to enable faster discovery of complex relationships across multi-omic data. Designed for researchers focused on genomics, proteomics, metabolomics, transcriptomics or any combination of life science disciplines, the package includes GeneSpring GX and Mass Profiler Professional, as well as Pathway Architect.

Researchers are expanding the applicability of biological circuits. Background: Microscopic image of human kidney cells with fluorescent proteins in cell culture.

Constructing Precisely Functioning, Programmable Bio-computers

October 23, 2014 3:40 pm | by Fabio Bergamin, ETH | News | Comments

Bio-engineers are working on the development of biological computers with the aim of designing small circuits made from biological material that can be integrated into cells to change their functions. In the future, such developments could enable cancer cells to be reprogrammed, thereby preventing them from dividing at an uncontrollable rate. Stem cells could likewise be reprogrammed into differentiated organ cells.

Diver collecting microbial samples from Australian seaweeds for Uncovering Genome Mysteries

Crowdsourced Supercomputing Examines Big Genomic Data

October 21, 2014 9:31 am | by IBM | News | Comments

What do the DNA in Australian seaweed, Amazon River water, tropical plants, and forest soil all have in common? Lots, say scientists. And understanding the genetic similarities of disparate life forms could enable researchers to produce compounds for new medicines, eco-friendly materials, more resilient crops, and cleaner air, water and energy.

The first act of copulation in our distant ancestors, Microbrachius dicki

Planet’s First Sex Act: Ancient Armored Fish did it Sideways

October 20, 2014 12:11 pm | by Flinders University | News | Comments

A profound new discovery reveals how the intimate act of sexual intercourse first evolved in our deep distant ancestors. In one of the biggest discoveries in the evolutionary history of sexual reproduction, Flinders University Professor John Long has found that internal fertilization and copulation was invented by ancient armored fishes, called placoderms, about 385 million years ago in Scotland.

A 500-million-year-old fossil used by Australian researchers to make their discovery about vetulicolians. These marine creatures had a rod through their tail similar to a backbone, which places them as distant cousins of vertebrate animals. Courtesy of Un

Bizarre Ancient Fossils Confirmed as Strange Human Cousins

October 16, 2014 2:50 pm | by University of Adelaide | News | Comments

More than 100 years since they were first discovered, some of the world's most bizarre fossils have been identified as distant relatives of humans. The fossils belong to 500-million-year-old blind water creatures, known to scientists as "vetulicolians" (pronounced: ve-TOO-lee-coal-ee-ans).

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Phylogenetic tree constructed with the BEAST software and built on a subset of both contemporary and ancient samples. Courtesy of Oxford University Press

Treasure Trove of Ancient Genomes Helps Recalibrate Human Evolutionary Clock

October 14, 2014 4:18 pm | by Molecular Biology and Evolution, Oxford University Press | News | Comments

To improve the modeling and reading of the branches on the human tree of life, researchers compiled the most comprehensive DNA set to date, a new treasure trove of 146 ancient (including Neanderthal and Denisovian) and modern human full mitochondrial genomes (amongst a set of 320 available worldwide).

“The collective expertise of NeuroLINCS investigators provides a unique opportunity to increase our knowledge of what makes brain cells unique and what happens during neurodegenerative diseases," said UC Irvine's Leslie M. Thompson.

Novel NIH Program will Create Database of Human Brain Cell Activity

October 10, 2014 12:08 pm | by UC Irvine | News | Comments

UC Irvine will receive $8 million from the NIH to establish one of six national centers dedicated to creating a database of human cellular responses that will accelerate efforts to develop new therapies for many diseases. The center will partner with researchers from Cedars-Sinai Medical Center’s Regenerative Medicine Institute, the Gladstone Institute of Neurological Disease, UC San Francisco, Johns Hopkins University and MIT.

Tom Conte is President-elect, IEEE Computer Society; Professor of Computer Science and Electrical & Computer Engineering, Georgia Institute of Technology; and Elie Track is President, IEEE Council on Superconductivity; CEO, nVizix.

Technology Time Machine Looks Far Ahead at Future of Processing

October 7, 2014 3:25 pm | by Tom Conte and Elie Track, IEEE | Blogs | Comments

The IEEE Technology Time Machine (TTM) is going further into the future. Now in its third year, the annual two-day IEEE meeting is mixing things up a little in terms of format and topics. Rather than just looking at how some technologies might evolve in the next decade, experts and visionaries are going to look out to 2035 and beyond.

This 600X photograph of a Drosophila melanogaster (fruit fly) seminal vesicle received an Image of Distinction designation in the 2013 Nikon Small World Photomicrophotography Competition, which recognizes excellence in photography with the optical microsc

Fruit Fly Privates

October 3, 2014 2:57 pm | News | Comments

This 600X photograph of a Drosophila melanogaster (fruit fly) seminal vesicle received an Image of Distinction designation in the 2013 Nikon Small World Photomicrophotography Competition, which recognizes excellence in photography with the optical microscope. The confocal image was created by Barbara Laurinyecz of University of Szeged, Department of Genetics, Szeged, Hungary using fluorescence.

Caris Life Sciences is accelerating precision medicine for cancer treatment using IBM technical computing and software defined storage solutions.  Courtesy of Caris Life Science

Accelerating Use of Molecular Profiling in Cancer Treatment Selection

September 25, 2014 4:43 pm | by IBM | News | Comments

IBM announced that Caris Life Sciences is using IBM technical computing and storage technology to accelerate the company’s molecular profiling services for cancer patients. The Caris tumor profiling database is one of the largest datasets in the application of advanced molecular profiling technologies to support clinicians in delivering personalized treatment recommendations — or precision oncology.

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Scaffolded DNA origami utilizes numerous chemically synthesized, short DNA strands (staple strands) to direct the folding of a larger, biologically derived strand of DNA (scaffold strand). Molecular recognition (base pairing, i.e., A binds to T and G bind

Researchers Create World’s Largest DNA Origami

September 11, 2014 4:48 pm | by North Carolina State University | News | Comments

Researchers from North Carolina State University, Duke University and the University of Copenhagen have created the world’s largest DNA origami, which are nanoscale constructions with applications ranging from biomedical research to nanoelectronics. The standard for DNA origami has long been limited to a scaffold strand that is made up of 7,249 bases. The research team has now created DNA origami consisting of 51,466 bases

University of Chicago Paleontologist Paul C. Sereno looks inside the jaws of a 50-foot life-size model of a Spinosaurus dinosaur at the National Geographic Society exhibit in Washington. (AP Photo/Pablo Martinez Monsivais)

Bizarre, Alien-like Giant Dinosaur Unveiled

September 11, 2014 4:33 pm | by Seth Borenstein, AP Science Writer | News | Comments

Picture the fearsome creatures of "Jurassic Park" crossed with the shark from "Jaws." Then, super-size to the biggest predator ever to roam Earth. Now, add a crocodile snout as big as a person and feet like a duck's. The result gives you some idea of a bizarre dinosaur scientists unveiled September 11, 2014. This patchwork of critters, a 50-foot predator, is the only known dinosaur to live much of its life in the water.

Parents and physicians and scientists from the Neuroblastoma and Medulloblastoma Translational Research Consortium and TGen have teamed to launch a groundbreaking personalized medicine clinical trial investigation for pediatric cancer.

Providing Critical Child-cancer Research Tools to Speed Development of Personalized Treatments

September 11, 2014 3:25 pm | by TGen | News | Comments

Dell, Terascala and the Translational Genomics Research Institute are installing state-of-the-art computing and programing specialized for human genome investigations at the National Cancer Institute. The mission of the Oncogenomics Section at the NCI is to harness the power of high throughput genomic and proteomic methods to improve the outcome of children with high-risk metastatic, refractory and recurrent cancers.

The industry's preeminent event on Molecular Medicine, focusing on Drug Discovery, Genomics, Diagnostics and Information Technology.

22nd International Molecular Medicine Tri-Conference

August 28, 2014 3:17 pm | Events

The 22nd International Molecular Medicine Tri-Conference is the industry's Preeminent Event on Molecular Medicine, focusing on Drug Discovery, Genomics, Diagnostics and Information Technology. Spanning six days this year, the Tri-Conference includes an expanded program that includes 6 symposia, over 20 short courses, and 17 conference programs.

As advances in technology allow researchers to gather more and more morphological and image-based data, it has become increasingly important to be able to analyze and interpret those data quickly, accurately, consistently, and objectively. Biometric and b

Humans and Computers Figure Out the Plant World Together

August 28, 2014 1:30 pm | by American Journal of Botany | News | Comments

As advances in technology allow researchers to gather more and more morphological and image-based data, it has become increasingly important to be able to analyze and interpret those data quickly, accurately, consistently, and objectively. Biometric and bioinformatic methods make this possible, and reveal the potential of data collected from the shape and form of plants to be as rich of a data source as genetic data.

Pathogenic bacteria (red) live side-by-side with benign species (green) in a healthy mouth. Scientists are beginning to understand what causes bacterial communities to shift from health to diseases like periodontitis, diabetes, and Crohn's disease. Courte

Mouth Bacteria Can Change its Diet, Supercomputers Reveal

August 22, 2014 12:28 pm | by Jorge Salazar, TACC | News | Comments

Bacteria inside your mouth drastically change how they act when you're diseased. Scientists say these surprising findings might lead to better ways to prevent or even reverse the gum disease periodontitis, diabetes and Crohn's disease. UT Austin researchers used shotgun metagenomic sequencing, a non-targeted way to study the all the genetic material of the bacterial communities. They analyzed the RNA collected with  Lonestar and Stampede.

Fossil Hallucigenia sparsa from the Burgess Shale Courtesy of M. R. Smith / Smithsonian Institute

Strangest Creature of Ancient Earth linked to Modern Animals

August 19, 2014 3:08 pm | by University of Cambridge | News | Comments

The spines along its back were thought to be legs, its legs thought to be tentacles along its back, and its head was mistaken for its tail. The animal, known as Hallucigenia due to its otherworldly appearance, had been considered an ‘evolutionary misfit’ as it was not clear how it related to modern animal groups. Researchers have discovered an important link...

Geneticist Assistant NGS Interpretative Workbench

Geneticist Assistant NGS Interpretative Workbench

August 18, 2014 3:42 pm | SoftGenetics, LLC | Product Releases | Comments

Geneticist Assistant NGS Interpretative Workbench features an Operational Management function with a unique workflow builder that permits users to mimic their physical workflow in “silico,” providing real‐time status tracking of samples throughout the workflow; operational statistics by department or function and automated e-mail notification of status changes.

George Vacek is life sciences global director at DataDirect Networks.

Enabling Innovation and Discovery through Data-Intensive High Performance Cloud and Big Data Infrastructure

July 29, 2014 2:34 pm | by George Vacek, DataDirect Networks | Blogs | Comments

As the size and scale of life sciences datasets increases — think large-cohort longitudinal studies with multiple samples and multiple protocols — so does the challenge of storing, interpreting and analyzing this data. Researchers and data scientists are under increasing pressure to identify the most relevant and critical information within massive and messy data sets, so they can quickly make the next discovery.

Genes that are active only in the testes have double the harmful mutation rate of those that are active in both sexes. Courtesy of Archaeogenetics

Mutations from Venus, Mutations from Mars: A Sex-difference Approach to Harmful Mutation

July 28, 2014 5:36 pm | by Weizmann Institute of Science | News | Comments

Some 15 percent of adults suffer from fertility problems, many of these due to genetic factors. This is something of a paradox: We might expect such genes, which reduce an individual's ability to reproduce, to disappear from the population. Recent research may have solved the riddle. Not only can it explain the high rates of male fertility problems, it may open new avenues in understanding the causes of genetic diseases and their treatment.

SLAS2015

July 11, 2014 10:24 am | by SLAS | Events

SLAS is a global organization that provides forums for education and information exchange to encourage study and professional collaboration aimed at advancing laboratory science and technology for the drug discovery, biotechnology, chemical, data informatics, clinical diagnostic, consumer product, pharmaceutical, and other industries.

Bottom-up Proteomics: Supercomputer helps Researchers Interpret Genomes

July 9, 2014 3:30 pm | by NSF | News | Comments

Tandem protein mass spectrometry is one of the most widely used methods in proteomics, the large-scale study of proteins, particularly their structures and functions. Researchers in the Marcotte group at the University of Texas at Austin are using the Stampede supercomputer to develop and test computer algorithms that let them more accurately and efficiently interpret proteomics mass spectrometry data.

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