Advances in technology have generated vast amounts of “omics” data: genomic, epigenomic, transcriptomic, proteomic and metabolomic changes for all types of specimens. Bridging the gap between data generation and investigators’ ability to retrieve and interpret data is essential to realize the biological and clinical value of this wealth of information.
Qlucore is a software platform for the analysis of genomics, proteomics and related data. As...
In the decade since the genome was sequenced, scientists and doctors have struggled to answer an...
Tandem protein mass spectrometry is one of the most widely used methods in proteomics, the large-scale study of proteins, particularly their structures and functions. Researchers in the Marcotte group at the University of Texas at Austin are using the Stampede supercomputer to develop and test computer algorithms that let them more accurately and efficiently interpret proteomics mass spectrometry data.
Dr. Collins is the director of the Advanced Biomedical Computing Center at the Frederick National Laboratory for Cancer Research. Dr. Collins’ research focuses on biomedical computing applications pertaining to cancer. His research group develops and applies high-performance algorithms to solve data-intensive computational biology problems in the areas of genomic analysis, pattern recognition in proteomics and imaging, molecular modeling, and systems biology.
Is Big Data really the biggest challenge at the moment for translational science? Certainly there are issues with the complexity and size of omics data, which Big Data techniques can help address, but there are two more pressing challenges: enabling collaboration whilst facilitating information sharing, and the ability to better interpret multiple different omics data (multi-omics).
This image of a pelagosphera larva of Nephasoma pellucidum (peanut worm) after four days of development won an Honorable Mention in the 2013 Nikon Small World Photomicrophotography Competition. The 40x confocal image was submitted by Dr. Michael J. Boyle of the Smithsonian Institution at Smithsonian Marine Station, Fort Pierce, Fla.
An international team of scientists led by National Institutes of Health researchers has traced the likely origin of the enzyme needed to manufacture the hormone melatonin to roughly 500 million years ago.
Waters Corporation has announced the acquisition of Nonlinear Dynamics Ltd., a proteomics and metabolomics analysis software company based in Newcastle upon Tyne, U.K. Nonlinear Dynamics is best known for its Progenesis software, which offers researchers unique ways to analyze and visualize the raw proteomic data.
Neurodegenerative diseases such as Alzheimer's could be better understood thanks to insight into proteins linked to such conditions, a study suggests. Scientists studying thread-like chains of protein – called amyloid fibres – have found that low levels of these proteins may cause more harm to health than high levels.
Wolfgang Bettighofer of Dataport in Kiel, Germany created this 250x image using differential interference contrast. The photograph of Mediopyxis helysia (diatom) was an Image of Distinction in the 2012 Nikon Small World Photomicrophotography Competition.
It's not a hacker lab. At Brandeis University, sophisticated computational models and advances in graphical processing units are helping scientists understand the complex interplay between genomic data, virus structure and the formation of the virus' outer "shell" — critical for replication.
A yet unidentified component of coffee interacts with the beverage’s caffeine, which could be a surprising reason why daily coffee intake protects against Alzheimer’s disease. A new Alzheimer’s mouse study found that this interaction boosts blood levels of a critical growth factor that seems to fight off the Alzheimer’s disease process
A new international study confirms that whilst snow has an insulating effect which helps plants to grow bigger, heavy and prolonged snow can, in certain circumstances, also encourage the rapid and extensive growth of killer fungal strains. The snowfall can bring about unexpected conditions that encourage fungal growth, leading to the death of plants in the Arctic
For migratory birds and sea turtles, the ability to sense the Earth’s magnetic field is crucial to navigating the long-distance voyages these animals undertake during migration. Humans, however, are widely assumed not to have an innate magnetic sense. But new research shows that a protein expressed in the human retina can sense magnetic fields when implanted into Drosophila
A biologist has discovered a ‘lost’ species of bat breeding on the Isles of Scilly. A pregnant female brown long-eared bat is the first of its species to be found on the islands for at least 40 years
The Arabian Oryx, a species of antelope found only on the Arabian Peninsula. It is believed the last wild individual was shot in 1972. This year the oryx has finally qualified for a move from the Endangered category to Vulnerable the first time that a species that was once Extinct in the Wild has improved by three categories
There is a a higher DNA mutation rate in mammalian males than in mammalian females, a phenomenon called male mutation bias. A new study shows that generation time is the main determinant of this phenomenon
A team of researchers have discovered that, on average, thirty mutations are transmitted from each parent to their child, revising previous estimations and revolutionizing the timescale we use to calculate the number of generations separating us from other species
In the 1960s and '70s a marine biologist at California's Scripps Institution of Oceanography (SIO), set out on field expeditions to remote places to study the fish of the Pacific Ocean. But due primarily to a lack of space at SIO, much of the treasure trove remained unsorted until now
Deadly bacteria may be evolving antibiotic resistance by mimicking human proteins, according to a new study. This process of “molecular mimicry” may help explain why bacterial human pathogens, many of which were at one time easily treatable with antibiotics, have re-emerged in recent years as highly infectious public health threats
Dual regulation may provide a test of two distinct regulatory approaches. The U.S. Food and Drug Administration (FDA) has been provided by Congress with new and wide-ranging responsibilities in food regulation. Overlapping responsibilities of the U.S. Department of Agriculture (USDA) have not been reduced, however, creating a potential for dual regulation and the confusions and contradictions that split responsibility can bring
In a finding that upends decades of scientific theory on reptile reproduction, researchers have discovered that female boa constrictors can have babies without mating. More strikingly, the finding shows that the babies produced from this asexual reproduction have attributes previously believed to be impossible
A research team reports on a new cell model they have developed to investigate brain diseases based on patient-derived stem cells. They get the stem cells from an accessible part of the nervous system, the olfactory organ of the sense of smell in the nose
The patented microchip has the size of a one euro coin, incorporating a small channel along which a sample of blood containing the patient's tumor cells flows. By means of ultrasonic waves focused on a specific zone, these cells, having a density and size different from the rest, concentrate at the point from where they are gathered
The Nobel Prize in medicine went to a man whose work led to the first test tube baby, an achievement that helped bring 4 million infants into the world and raised challenging new questions about human reproduction. Robert Edwards of Britain lived to see the far-reaching ramifications of his hugely controversial early research
Pinpoint software is designed to bridge the transition from early-stage biomarker discovery to larger-scale, quantitative verification of putative biomarkers and general quantitative proteomics
There are presently hundreds of papers published weekly in the area of genomics, in silico modeling and drug discovery. This month’s rant will briefly explore the current state of affairs, probe for weakness, especially non-informative “discovery,” and offer a bit of guidance
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